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design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 277-284 doi: 10.1007/s11684-018-0630-3

Abstract: The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa valuesDrug-likeness screening was further conducted to obtain the candidates that significantly reduced the adverse

Keywords： proton-pump inhibitor     adverse effect     pharmacological mechanism     toxicological mechanism     pKa calculation    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related adverse

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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The Ejection and Sweep in the Wall Region of a Turbulent Boundary Layer Under Adverse Pressure Gradient

Zhang Qiang,Lu Lipeng

Strategic Study of CAE 2003, Volume 5, Issue 11,   Pages 47-50

Abstract:

The evolution of coherent structures in the wall region of a turbulent boundary layer under adversethat to the shear stress, the contribution of sweep motions is stronger than that of ejections under adversethe transport of shear-stress and kinetic energy of turbulence more strongly than the ejections under adverse

Keywords： coherent structures     turbulent boundary layer     adverse pressure gradients     direct numerical simulation    

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surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverse

Fei Liu, Li Liu, Fang Zheng, Xiangdong Tang, Yongxin Bao, Yunxia Zuo

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 189-195 doi: 10.1007/s11684-017-0533-8

Abstract: are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverseFurthermore, the incidence of adverse respiratory events in the PACU was higher in patients with highAge, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory

Keywords： obstructive sleep apnea     Berlin Questionnaire     Chinese surgical patients     adverse respiratory event    

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An analysis of the adverse reactions of five kinds of intrauterine devices

Li Huajie

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 28-30

Abstract: device (IUD), Aimu ring (MCU), maternal music MCU375, uterine shaped ring GCU300, TCU220C and genefex of adverseThe adverse reactions of MCU375 were serious, the adverse reactions of GCU300 and MCU were followed,and the adverse reactions of TCU220c and Ji Nihuan were the lightest..

Keywords： IUD     adverse reaction     Jeanne ring    

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Adverse Geology Identification Through Mineral Anomaly Analysis During Tunneling: Methodology and Case Article

Zhenhao Xu, Tengfei Yu, Peng Lin, Shucai Li

Engineering 2023, Volume 27, Issue 8,   Pages 150-160 doi: 10.1016/j.eng.2022.09.013

Abstract: span style="font-size:10.5pt">Accurate and effective identification of adverseCurrent methods of identifying adverse geology depend on the experience of geologists and are prone toHere, we propose a method for adverse geology identification in tunnels based on mineral anomaly analysisThe proposed method provides a timely warning when a tunnel enters areas affected by adverse geologyThis method improves our ability to identify adverse geology, from qualitative to quantitative, and can

Keywords： Mineral anomaly     Adverse geology     Fault     Alteration     Anomaly threshold    

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Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: inhibitors, and discusses the advantages of combination therapy, as well as the risk of immune-related adverse

Keywords： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 20-31 doi: 10.1007/s11684-016-0493-4

Abstract: Gastrointestinal fluid examination could also predict the adverse effects of postgastrectomy, such as

Keywords： gastrointestinal fluid     gastric carcinoma     biomarker     diagnosis     prognosis     gastrectomy     adverse events    

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The Practice of Forward Prospecting of Adverse Geology Applied to Hard Rock TBM Tunnel Construction: Article

Shucai Li, Lichao Nie, Bin Liu

Engineering 2018, Volume 4, Issue 1,   Pages 131-137 doi: 10.1016/j.eng.2017.12.010

Abstract: However, when a TBM encounters adverse geological conditions in the course of tunnel construction (e.gTherefore, the advance detection of adverse geology and water-bearing conditions in front of the tunnelThis prospecting technical system also has reference value for carrying out the forward prospecting of adverse

Keywords： tunnels     Comprehensive forward prospecting     Geological analysis     3D induced polarization     3D seismic method     Adverse    

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Analysis of effect of different construction methods of piles on the end effect on skin friction of piles

ZHOU Hongbo, CHEN Zhuchang

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 4,   Pages 458-463 doi: 10.1007/s11709-007-0062-7

Abstract: Based on the comparative analysis of end effect on skin friction of displacement-pile (driven pile),the end effect on skin friction of bored pile is studied.The end effect on skin friction between driven pile and bored pile is different and the end effect onThe concept of additional mud cake formed by the effect of cushion at the bottom of borehole during pouringconcrete is introduced to explain the mechanism of end effect on skin friction of the bored pile.

Keywords： distance     different     concept     additional     bottom    

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A review on different theoretical models of electrocaloric effect for refrigeration

Frontiers in Energy 2023, Volume 17, Issue 4,   Pages 478-503 doi: 10.1007/s11708-023-0884-6

Abstract: The performance parameters for characterizing the electrocaloric effect are isothermal entropy changeThis paper reviews the electrocaloric effect of ferroelectric materials based on different theoreticalsimulation, and finite element analysis) to explain the basic theory of calculating the electrocaloric effectThen, it comprehensively reviews the recent progress of these methods in regulating the electrocaloric effectand the generation mechanism of the electrocaloric effect.

Keywords： electrocaloric effect     effective Hamiltonian     phase-field modeling     different theoretical models    

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A new miniaturized engine based on thermomagnetic effect of magnetic fluids

Lujun ZHOU, Yimin XUAN, Qiang LI, Wenlei LIAN

Frontiers in Energy 2009, Volume 3, Issue 2,   Pages 160-166 doi: 10.1007/s11708-009-0018-9

Abstract: NdFeB magnet, a kerosene-based magnetic fluid and a rotor, is proposed based on the thermomagnetic effect

Keywords： magnetic fluid     thermomagnetic effect     engine    

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The chromosome breakage rates in 244 cases of the infertility couples

Yu Hongliang,Chang Mingxiu,Cao Henghai,Bo Liwei,Wang Yanli and Wu Yanhong

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 67-69

Abstract:

To understand the incidence of chromosome breakage rates for the adversecouples，we analyzed statistically the chromosomal breakage rates in the infertility couples which have adversechromosomal breakage may be one of the important reasons for embryo damage、miscarriage and other the adverse

Keywords： infertility couples     adverse pregnancy     chromosome breakage    

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Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristics of Cd and As under joint stress of Cd and As

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1,   Pages 107-113 doi: 10.1007/s11783-007-0020-6

Abstract: The results showed that Cd and As had an antagonistic effect on enhancing the growth of plants and CdHowever, there were synergic adverse effects on plant growth and Cd uptake under the combined pollutionfactor (TF) was "d0.3 and the bioaccumulation factor (BF) was "d0.6, thus showing that had an excluding effect

Keywords： synergic adverse     stress     present study     potential     weight    

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Title Author Date Type Operation

design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

The Ejection and Sweep in the Wall Region of a Turbulent Boundary Layer Under Adverse Pressure Gradient

Zhang Qiang,Lu Lipeng

Journal Article

surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverse

Fei Liu, Li Liu, Fang Zheng, Xiangdong Tang, Yongxin Bao, Yunxia Zuo

Journal Article

An analysis of the adverse reactions of five kinds of intrauterine devices

Li Huajie

Journal Article

Adverse Geology Identification Through Mineral Anomaly Analysis During Tunneling: Methodology and Case

Zhenhao Xu, Tengfei Yu, Peng Lin, Shucai Li

Journal Article

Multi-target combinatory strategy to overcome tumor immune escape

Journal Article

Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Journal Article

The Practice of Forward Prospecting of Adverse Geology Applied to Hard Rock TBM Tunnel Construction:

Shucai Li, Lichao Nie, Bin Liu

Journal Article

Li Haoran: Research on the Transformation Decision of "Replacing Coal With Gas" Based on Peer Effectand Network Effect (2020-7-11)

19 May 2022

Conference Videos

Analysis of effect of different construction methods of piles on the end effect on skin friction of piles

ZHOU Hongbo, CHEN Zhuchang

Journal Article

A review on different theoretical models of electrocaloric effect for refrigeration

Journal Article

A new miniaturized engine based on thermomagnetic effect of magnetic fluids

Lujun ZHOU, Yimin XUAN, Qiang LI, Wenlei LIAN

Journal Article

The chromosome breakage rates in 244 cases of the infertility couples

Yu Hongliang,Chang Mingxiu,Cao Henghai,Bo Liwei,Wang Yanli and Wu Yanhong

Journal Article

Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristics of Cd and As under joint stress of Cd and As

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

Journal Article